Vascular Disrupting Agents
نویسندگان
چکیده
منابع مشابه
Antiangiogenic and vascular-disrupting agents in endometriosis: pitfalls and promises.
It is widely known that angiogenesis plays a key role in endometriotic lesion formation and development. Antiangiogenic treatments aimed at inhibiting new vessel formation have proven efficient in experimental models. However, as antiangiogenic strategies do not target pre-existing pericyte-protected vessels, they require chronic administration and are likely to be beneficial for early-stage di...
متن کاملTumor resistance to vascular disrupting agents: mechanisms, imaging, and solutions
The emergence of vascular disrupting agents (VDAs) is a significant advance in the treatment of solid tumors. VDAs induce rapid and selective shutdown of tumor blood flow resulting in massive necrosis. However, a viable marginal tumor rim always remains after VDA treatment and is a major cause of recurrence. In this review, we discuss the mechanisms involved in the resistance of solid tumors to...
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A tumor's support system — its existing blood vessels, or vasculature — nourishes the tumor by supplying oxygen and nutrients, allowing it to grow, spread, and often turn lethal. Antiangiogenesis approaches attempt to prevent the formation of these blood vessels, but researchers are also focused on targeting the established vasculature in hopes of destroying tumors by obliterating the blood ves...
متن کاملAnticancer potential of tumor vascular disrupting agents: review of the latest clinical evidence
Solid tumors differ from normal tissue by having a low vascular density, leading to various forms of vascular stress. Tumor vascular disrupting agents (VDAs) act to potentiate this stress, increasing vascular permeability and decreasing blood flow. Two main classes of tumor VDAs have progressed so far to clinical trial: the ‘flavonoid’ class, represented by vadimezan, and the tubulin poisons, r...
متن کاملReversing resistance to vascular-disrupting agents by blocking late mobilization of circulating endothelial progenitor cells.
UNLABELLED The prevailing concept is that immediate mobilization of bone marrow-derived circulating endothelial progenitor cells (CEP) is a key mechanism mediating tumor resistance to vascular-disrupting agents (VDA). Here, we show that administration of VDA to tumor-bearing mice induces 2 distinct peaks in CEPs: an early, unspecific CEP efflux followed by a late yet more dramatic tumor-specifi...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2010
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000391376.09556.d8